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How effective is in vitro fertilization, and how can it be improved?
Stewart LM, et al. Fertil Steril in press 2011
IVF effectiveness could be improved if women, particularly those over 35, underwent more cycles
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Follicle-stimulating hormone administered at the time of human chorionic gonadotropin trigger improves oocyte developmental competence in in vitro fertilization cycles: a randomized, double-blind, placebo-controlled trial
Lamb JD, et al. Fertil Steril in press 2011
Improvements in IVF success rates have largely been due to optimization of embryo culture and stimulation protocols; less attention has been directed toward methods to improve induction of final oocyte maturation. This was the first randomized, double-blind, placebo-controlled trial to modify the ovulation trigger to improve oocyte competence, as demonstrated by the statistically significant improvement in fertilization.
Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study
Chiu RWK, et al. BMJ Online First 2011;342:c7401
Multiplexed maternal plasma DNA sequencing analysis could be used to rule out fetal trisomy 21 among high risk pregnancies. If referrals for amniocentesis or chorionic villus sampling were based on the sequencing test results, about 98% of the invasive diagnostic procedures could be avoided
Report on a consecutive series of 581 children born after blastomere biopsy for preimplantation genetic diagnosis
Liebaers I, et al. Human Reproduction, Vol.25, No.1 pp. 275–282, 2010
Embryo biopsy does not add risk factors to the health of singleton children born after PGD or PGS. The perinatal death rate in multiple pregnancies is such that both caution and long-term follow-up are required.
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